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Specifically, a cell-surface receptor protein called protocadherin-1 PCDH1commonly associated with human asthma, is responsible for facilitating lung cell infection and triggering HPS.
For decades, scientists have been attempting to identify the host molecules that mediate hantavirus infection and lead to HPS, which has a case fatality rate of percent. Currently there are no licensed vaccines, prophylactics, or therapeutics to prevent or treat this highly pathogenic disease, which is transmitted to humans by infected rodents.
The study was co-led by John M. Through a genetic screen, the research team discovered that new world hantaviruses found in North and South America Sin Nombre virus and Andes virus, respectively were unable to infect cells when PCDH1 was "knocked out.
In the midst of an unexplained outbreak of severe respiratory distress in several western states, USAMRIID and the Centers for Disease Control and Prevention worked jointly to confirm that the disease was caused by a hantavirus that had not previously been reported.
This hamster model laid the groundwork for further research, including the study published today. Research conducted at USAMRIID leads to medical solutions--vaccines, drugs, diagnostics, and information--that benefit both military personnel and civilians.
Army Medical Research and Materiel Command.
For more information, visit http:Priorities for future research suggest an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.
which is now called hantavirus pulmonary syndrome (HPS) or hantavirus. A global team of investigators has identified a key protein involved in Hantavirus Pulmonary Syndrome (HPS), a serious and sometimes fatal respiratory disease, according to research published today in .
In the United States, another strain results in hantavirus pulmonary syndrome.
Early symptoms mimic influenza; they include fever, chills, muscle aches, nausea and vomiting, malaise, and a dry cough. Hantavirus pulmonary syndrome is an infectious disease characterized by flu-like symptoms that can progress rapidly to potentially life-threatening breathing problems.
Several types of hantaviruses can cause hantavirus pulmonary syndrome. diseases—Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, the latter having a fatality rate of above 40 %. Although considerable research for over two of a research paper could reveal the exchange of knowledge among researchers in their effort to bring out a published paper.
Similarly, the afﬁliation details in. Hantavirus News and Research RSS. Simple paper strip test can rapidly diagnose Ebola. researchers have developed an animal model of human hantavirus pulmonary syndrome (HPS) .